LuminalB-Breast-MR-Enhancement | Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging
DOI: 10.7937/K9/TCIA.2014.IIRMBUNX | Data Citation Required | Analysis Result
| Location | Subjects | Updated | ||
|---|---|---|---|---|
| Breast Cancer | Breast | 48 | 2014/11/12 |
Summary
To investigate associations between breast cancer molecular subtype and semiautomatically extracted magnetic resonance (MR) imaging features. Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive for 48 patients with breast cancer from four institutions in the United States were used in this institutional review board approval-exempt study. Computer vision algorithms were applied to extract 23 imaging features from lesions indicated by a breast radiologist on MR images. Morphologic, textural, and dynamic features were extracted. Molecular subtype was determined on the basis of genomic analysis. Associations between the imaging features and molecular subtype were evaluated by using logistic regression and likelihood ratio tests. The analysis controlled for the age of the patients, their menopausal status, and the orientation of the MR images (sagittal vs axial). There is an association (P = .0015) between the luminal B subtype and a dynamic contrast material-enhancement feature that quantifies the relationship between lesion enhancement and background parenchymal enhancement. Cancers with a higher ratio of lesion enhancement rate to background parenchymal enhancement rate are more likely to be luminal B subtype. The luminal B subtype of breast cancer is associated with MR imaging features that relate the enhancement dynamics of the tumor and the background parenchyma. (c) RSNA, 2014 Online supplemental material is available for this article.Purpose
Materials and Methods
Results
Conclusion
Collections Used In This Analysis Result
| Title | Data Type | Format | Access Points | Subjects | License | |||
|---|---|---|---|---|---|---|---|---|
| Original Image Data from TCGA-BRCA | MR | DICOM | Requires NBIA Data Retriever |
48 | 51 | 528 | 55,953 | CC BY 3.0 |
Citations & Data Usage Policy
Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:
Data Citation |
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Mazurowski MA, Zhang J, Grimm LJ, Yoon SC, and Silber JI. (2014). Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging (LuminalB-Breast-MR-Enhancement). The Cancer Imaging Archive. DOI: 10.7937/K9/TCIA.2014.IIRMBUNX |
Related Publications
Publications by the Dataset Authors
The authors recommended the following as the best source of additional information about this dataset:
Publication Citation |
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Mazurowski, M. A., Zhang, J., Grimm, L. J., Yoon, S. C., & Silber, J. I. (2014). Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging. Radiology. Radiological Society of North America (RSNA). DOI: 10.1148/radiol.14132641 |
Research Community Publications
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