The Cancer Imaging Archive

Advanced-MRI-Breast-Lesions | Standard and Delayed Contrast-Enhanced MRI of Malignant and Benign Breast Lesions with Histological and Clinical Supporting Data

DOI: 10.7937/C7X1-YN57 | Data Citation Required | 1.5k Views | 1 Citations | Image Collection

Summary

The application of deep-learning methods to breast MRI has a potential to improve diagnosis as well as predict pathological features of the tumors and their response to therapy, and is currently widely investigated. Standard contrast-enhanced MRI of the breast provides high sensitivity but variable specificity in detecting breast cancer, and may lead to excessive benign biopsies. Large, well annotated datasets are needed to improve the current results in this field.

This dataset is a single-institutional, retrospective collection of 632 breast-MRI imaging sessions acquired on a 1.5T MR system between 2018-2021. Supporting data, collected for 200 patients from clinical notes, radiology reports and pathology reports, is included: patient age, lesion location, malignant/benign outcome, pathology and grade (if applicable), receptor status and KI67 (if applicable).

All enhancing/suspicious positions that were mentioned in the radiological reports were first delineated manually by a certified radiologist with 23 years of experience. Then, these regions were thresholded automatically, keeping the pixels in which the intensity of the first/second subtracted images (subtraction of the pre-contrast image from the first/second post-contrast image) were above the threshold of 75.

The main uniqueness of this data is that it contains the standard protocol series (T1-weighted DCE sequence with 5 time points- before and 4 time points after contrast injection, and T2-weighted MRI with/without fat suppression) as well as the delayed contrast T1-images acquired 20-28 minutes after contrast administration and the calculated treatment response assessment maps (TRAMs).

We recently introduced the utility of delayed-contrast MRI for calculating treatment response assessment maps (TRAMs) for improved specificity and accuracy in breast cancer diagnosis. The TRAMs are calculated by subtracting 3D T1-MRIs acquired 5 minutes post-contrast injection from those acquired ~22 minutes thus depicting the spatial distribution of contrast accumulation/clearance. Furthermore, the application of deep-learning methods to breast MRI has a potential to improve diagnosis as well as predict pathological features of the tumors and their response to therapy.

Data Access

Version 2: Updated 2024/04/15

SOP class UID was changed for all TRAM images from MR Image to Secondary Capture Image (623 series).

Additional Resources for this Dataset

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• Imaging Data Commons (IDC) (Imaging Data)

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